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performed in healthy,adult volunteers under rigid conditions of fasting and activitybecause the objective is to obtain quantitative information onthe influence of pharmaceutical formulation variables on thedrug product’s absorption. however, it is not the ambition of this book to offer a detailed description of allrelevant guidelines nor does it quote texts from these guidelines. theterminations of the accelerator nerve are unaffected, exactly as theterminations of the sympathetic in the salivary glands, and theheart muscle is neither stimulated nor depressed. attention and accessto the scientific and patent literature has accelerated. adipose tissue has almost as much water in it as other tis-sues, so that the apparent total volume of distribution of theophyl-line is proportional to body weight even in obese patients.abnormal accumulation of fluid edema, ascites, pleuraleffusion can markedly increase the volume of distribution ofdrugs such as gentamicin that are hydrophilic and have 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